Altern Med Rev 2000;5:334-46. 2016;928:329-373. doi:10.1007/978-3-319-41334-1_14. View abstract. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Ashwagandha has mild interactions with at least 29 different drugs. View abstract. Are there any side effects of ashwagandha? View abstract. Safety and adverse events were also not well-reported in the studies used in the review. No supplement is intended to treat, cure, or prevent disease. Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. Ashwagandha supplements are meant to be taken every day. Verywell Health's content is for informational and educational purposes only. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Ashwagandha can also interact with some medications and affect how they work. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. View abstract. Acta Nerv Super 1990;32(1):1-5. Some people may need to avoid taking Ashwagandha, however, including those who: Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Ashwagandha: Benefits, Side Effects, Dosage, and Interactions Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Arch Pathol Lab Med 2007;131:1298-303. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Several supplements and herbs may act similarly to ashwagandha. 13 Supplement or Medication Combos You Should Never Mix Can You Take A Z-Pak If You Have A Penicillin Allergy? Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. 2021;270:113766. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. Because ashwagandha supports immune system function, it might interact with medications designed to reduce immune system activity, known as immunosuppressants, according to the University of Maryland Medical Center. Skinmed. Biomed Res Int 2015;2015:284154.View abstract. J Diet Suppl. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. Hidese S, Ogawa S, Ota M, et al. Just be sure to choose a supplement from a reputable manufacturer and follow the . 2022 Mar 25;14(3):e23494. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. This dosing has also been associated with improvements in memory. Phytotherapy Research 1991;5:111-114. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. A systematic review and meta-analysis of randomized controlled trials. Read our. For most people, ashwagandha is a safe and effective supplement for taking the edge off stress. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Researchers of the study believed that these results were due to the ability of ashwagandha to moderate the body's stress response. Additionally, a pilot study looked at ashwagandha's effects on people with mild cognitive impairment. View abstract. Cureus. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Bull Natl Res Cent. . View abstract. Indian J Pharmacol. View abstract. Read More. View abstract. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. More are needed for more definitive results. Its botanical name is Withania somnifera and it is also known as "Indian ginseng . Ashwagandha may interact with various medications. View abstract. Levothyroxine (Synthroid) Supplement Interactions -- Supplements To A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Ireland PJ, Hardy T, Burt AD, Donnelly MC. Does Ashwagandha Interact With Any Medications? View abstract. Brain Behav. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. J Res Ayur Sid 1980;1:370-385. 2004;42(12):2015-2020. Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. View abstract. Consult your doctor before taking ashwagandha if you use digoxin. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. In recent years, some researchers have assessed how ashwagandha may benefit physical performance. It may also interact with medications for these conditions. View abstract. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. Indian J Psychol Med. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. 2020;10(11):e01760. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. Ahmad MK, Mahdi AA, Shukla KK, et al. This is one of the more common food-drug reactions. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Ashwagandha and other dietary supplements should never replace standard medicine or care. Some don't work well with prescription medicines. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. She founded the Fad Free Nutrition Blog and Nutricion al Grano websites and is based in Texas. Ashwagandha might lower blood pressure. Bjrnsson HK, Bjrnsson ES, Avula B, et al. You can mix other nonessential amino acids and antidepressants without any issues. 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. Taking it with drugs that increase levels of thyroid hormone (e.g. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. Durg S, Bavage S, Shivaram SB. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Ethnopharmacol 1999;64:91-3. Serotonin syndrome can even result in death. of signs you need emergency medical attention or call 911. Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. View abstract. View abstract. Compared to those who took the placebo, participants who took ashwagandha were found to have better visual memory, learning, and attention. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Long-term safety studies on ashwagandha are lacking. 1965;9(1):9-15. Vitamin Keven in foods such as kale, lettuce, broccoli, and chickpeascan counteract a blood thinner's benefits. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Cancer Lett. Levothyroxine is used to treat the following conditions: Hashimoto's disease. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. It is commonly used for stress. Health Sci Rep 2022;5(4):e741. Certain ingredients can influence the effectiveness of your antidepressants and how they affect your health. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective. Antidepressants come in various forms. Taking high doses of ashwagandha may increase your risk of side effects. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. metoprolol, nebivolol, propranolol), Diuretics (e.g. View abstract. National Library of Medicines list To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place. Adaptogenic Herbs And Their Interaction With Medications - Thyroid Nation As an adaptogen, helping the body resist physiological and psychological stress, Steroidal lactones (withanolides, withaferins), GLP-1 Agonists (e.g.